SIRT1 and Parkinson disease: The present study aims to compare serum levels of SIRT1, Nrf2, and NLRP3 between patients with PD and healthy controls, and to investigate the possible relationships between these biomarkers and clinical outcomes, including disease-related quality of life and fatigue, as assessed by the Parkinson’s Disease Questionnaire-39 (PDQ-39) and Parkinson’s Fatigue Scale-16 (PFS-16).