SIRT1 and Parkinson disease: Codolo et al. (2013) linked α-synuclein aggregates to NLRP3 inflammasome activation, emphasizing its role in PD pathology. Elevated NLRP3 alongside reduced SIRT1 and Nrf2 suggests a shift toward a pro-inflammatory, pro-oxidative state in PD, supporting the theory that oxidative stress and inflammasome-mediated inflammation act synergistically in disease progression (Lu et al., 2024).