NLRP3 and Parkinson disease: In contrast, NLRP3 levels were significantly elevated in PD patients, with a median of 411 pg./mL (IQR: 346.8–421.3) compared to 305 pg./mL (IQR: 225–310.5) in controls (Mann–Whitney U = 98, p = 0.006, r(b) = 0.78), reflecting increased inflammasome activation and systemic inflammation in PD.