Inter-marker relationships further supported this pattern—SIRT1 correlated positively with Nrf2 and inversely with NLRP3, while Nrf2 also showed a negative association with NLRP3—indicating that the balance between neuroprotective, antioxidant, and inflammatory pathways plays a central role in PD symptom burden beyond motor dysfunction. This evidence concerns the gene SIRT1 and Parkinson disease.