IL6 and endothelial dysfunction: Studies have shown that IL-6 directly impacts endothelial cells, inducing the production of various inflammatory cytokines and chemokines, thereby activating the coagulation cascade, leading to coagulopathy and vascular leakage (90).What’s more, IL-6 boosts the activity of the AT1R gene in endothelial cells, which could drive Ang II-induced vasoconstriction and the production of ROS, a major contributor to endothelial dysfunction (91).