CYP24A1 and glaucoma: <b>Methods</b>: A library of twelve novel <i>N</i>-aryl-2-(4-sulfamoylphenyl)hydrazine-1-carbothioamides <b>3</b> along with two new <i>N</i>-aryl-2-(4-sulfamoylphenyl)hydrazine-1-carboxamide derivatives <b>5</b> were synthesized and their inhibition abilities were tested against four human carbonic anhydrase isozymes (hCA I, II, IX and XII) related to some global diseases including glaucoma, cancer and osteoporosis.