<b>Methods</b>: A library of twelve novel <i>N</i>-aryl-2-(4-sulfamoylphenyl)hydrazine-1-carbothioamides <b>3</b> along with two new <i>N</i>-aryl-2-(4-sulfamoylphenyl)hydrazine-1-carboxamide derivatives <b>5</b> were synthesized and their inhibition abilities were tested against four human carbonic anhydrase isozymes (hCA I, II, IX and XII) related to some global diseases including glaucoma, cancer and osteoporosis. Here, CYP24A1 is linked to cancer.