In dark/fermented-tea models, teabrownins increase circulating GLP-1 and improve postprandial control in mice; in enteroendocrine secretin tumor cell-1 (STC-1) cells, they stimulate GLP-1 release—consistent with GPCR-based signaling from fermentation-derived polyphenols [153]. The gene discussed is GCG; the disease is neoplasm.