Complementing this, Lactobacillus plantarum ZJUFB2 in HFD-fed mice (16 weeks, approximately 109 CFU/day) improved glucose tolerance and insulin resistance, lowered circulating LPS and Lipopolysaccharide-binding protein (LBP), increased fecal SCFAs (notably acetate, i-butyrate, i-valerate; ↑ total SCFAs), and modulated bile-acid metabolism (↑ hepatic total bile acids alongside enrichment of bile-salt hydrolases (BSH)-containing taxa)—supporting an endotoxemia-to-insulin-sensitivity link [152]. The gene discussed is INS; the disease is Insulin resistance.