Another structurally related flavone, chrysin, has been reported to regulate glucose and lipid metabolism by modulating the AMPK/PI3K/Akt pathway in insulin-resistant HepG2 cells and in C57BL/6J mice with T2DM induced by a high-fat diet and streptozotocin (HFD/STZ model) [56]. This evidence concerns the gene INS and type 2 diabetes mellitus.