Correlations with Child-Pugh score, Barcelona Clinic Liver Cancer (BCLC) stage, and disease aetiology were evaluated.<h4>Results</h4>HCC patients exhibited significantly lower VDBP (177.3 ± 237.0 vs. 239.9 ± 141.9 mg/L, <i>p</i> < 0.001) and albumin (35.9 ± 5.4 vs. 48.0 ± 3.9 g/L, <i>p</i> < 0.001) compared to winter controls. The gene discussed is ALB; the disease is hepatocellular carcinoma.