In chemotherapy-resistant CRC cells, the expression of the anti-apoptotic protein Bcl-2 is significantly upregulated, while that of the pro-apoptotic protein Bax is significantly downregulated, confirming the presence of apoptosis suppression in drug-resistant CRC [45]; Concurrently, survivin, as an apoptosis-inhibiting protein, exhibits high expression closely associated with radiation resistance and apoptosis resistance in CRC cells [47,48]. The gene discussed is BIRC5; the disease is colorectal carcinoma.