In vivo, buccal EMPA-Cs/Fb/PLA NFs in an AlCl<sub>3</sub>-induced AD rat model significantly reduced brain-amyloid-β, phosphorylated tau, IL-1β, and AGER expression by 2.88-, 2.64-, 2.87-, and 2.50-fold, respectively, compared to positive controls, and improved locomotor activity (1.86-fold) and cognitive performance (T-maze) (4.17-fold). The gene discussed is MAPT; the disease is Alzheimer disease.