A complement to these approaches is the “CAR-TIL” strategy: autologous tumor-infiltrating lymphocytes, transiently electroporated with mRNA encoding an anti-HER2 CAR, restored cytotoxicity against UM 92-1 cells even after MHC-I knockout, hinting at a means to forestall antigen-loss escape [43]. Here, ERBB2 is linked to neoplasm.