TFRC and Iron deficiency anemia: Overall, these transcriptomic shifts resonate with phenotypic changes documented in these RYGB mice, including reduced plasma TG and LDL levels and consistent modulation of iron-related genes like Tfrc, Slc11a2 (Dmt1), Hamp, aligning with known iron deficiency patterns observed after RYGB [39] and in the previous study of these mice [5].