HPX and nutritional disorder: Although Hmox1 was not upregulated, several heme-scavenging genes (Hpx, Lrp1/Cd91) were induced, while others involved in heme or biliverdin handling (Slc48a1/Hrg1, Pgrmc1, Blvrb) were downregulated, suggesting a compensatory shift in heme-related processes consistent with iron deficiency.