For instance, Cyp2c29, Cyp3a11, Gsta2, and others each mapped to at least four functional categories, including “Chemical carcinogenesis,” “Drug metabolism—other enzymes,” and “Xenobiotic metabolic process.” This highlights a core cluster of detoxification enzymes that are strongly repressed under HF feeding, suggesting a broad hepatic vulnerability to xenobiotic and oxidative stress. The gene discussed is GSTA2; the disease is hydrops fetalis.