TNF and abscess: In a prospective study with 33 patients, the combination of anti-TNF agents mainly with ustekinumab, and only 1 patient with upadacitinib, resulted in clinical response—partial closure of the external fistula openings and/or a decrease in pain and discharge under pressure without abscesses—in 48.5% of patients, and in 24.2% complete radiological response, defined as MAGNIFI-CD score of 0.