The main objectives of the present study were to test differences in distributions of paraclinical parameters between preterm neonates with clinical early-onset sepsis (clinEOS) and those without clinical early-onset sepsis (Non-clinEOS) and to quantify the effects of TLR2, TLR4, IL6, and IL10 gene polymorphisms on clinical early-onset sepsis susceptibility. Here, TLR4 is linked to Sepsis.