C-reactive protein (CRP), a widely available biomarker of systemic inflammation, has also gained renewed interest, as elevated CRP levels correlate with inflammaging and greater sarcopenia severity—more specifically with decreased handgrip and knee extension strength; however, recent analyses emphasize that CRP should be used only as part of an integrated diagnostic algorithm rather than as an isolated marker, due to its lack of disease specificity and susceptibility to false-positive results in multimorbid patients [59]. The gene discussed is CRP; the disease is sarcopenia.