ADIPOQ and Hypertension: For example, response to dietary restrictions/changes is associated with ADIPOQ genotypes; for example, subjects with the GG genotype of an ADIPOQ rs1501299 gene variant showed better improvement in adiponectin levels and metabolic profile compared to T allele carriers [39] in obese subjects who also showed lack of response to hypocaloric diet if they carried the T allele of ADIPOQ gene variant (rs1501299) [40] while dietary approaches to stop hypertension (DASH) only lowered hypertension in patients with TT genotype [41].