For example, Borrelia burgdorferi (B. burgdorferi) infection of MDA-MB-231 cells can lead to upregulation of the chemokine family (CXCL1, 2, 3, 8, and 10) and CCL20 and activate NF-κB signaling, increasing the secretion of inflammatory factors IL-3, 4, 10, and 17 [72], collectively contributing to cancer progression. The gene discussed is NFKB1; the disease is cancer.