NFKB1 and cancer: Apart from the direct impact on BC cells and DNA mutations, ROS and RNS can in turn drive TME [61], shape a pro-cancer microenvironment, activate important signaling pathways such as NF-κB and MAPK, inhibit the function of natural killer cells (NK cells) and T cells, and recruit immunosuppressive cells such as Tregs or myeloid-derived suppressor cells (MDSCs).