SARS-CoV-2 S protein has been shown to increase the production of inflammatory cytokines IL-6, TNF-α, and IL-1β by BV-2 microglial cells [8], elevate TNF-α production in brain tissue [5], stimulate microglial oxygen consumption [9], cause activation of monoamine oxidase in neuroblastoma cells [10], stimulate purinergic signaling [11], and induce NLRP3 inflammasome activation [12]. The gene discussed is TNF; the disease is neuroblastoma.