Although detailed histopathologic subclassification was not available in the AACR GENIE dataset, the inclusion of biologically diverse adenocarcinoma cases underscores the importance of comprehensive genomic characterization to identify shared, subtype-agnostic molecular drivers that may inform prognosis and therapeutic targeting amplifications of ERBB2, which have potential therapeutic relevance based on prior studies in gynecologic malignancies. The gene discussed is ERBB2; the disease is adenocarcinoma.