In contrast, luminal subtype cancers (ER/PR-positive, usually lower grade) more frequently appear as spiculated masses with heterogeneous internal enhancement, and HER2-positive tumors are sometimes associated with pleomorphic microcalcifications due to accompanying Ductal Carcinoma In Situ (DCIS) [15,18]. This evidence concerns the gene ERBB2 and ductal breast carcinoma in situ.