In colon cancer, BRIP1 expression demonstrated significant associations with female (55.6% vs. 45.3%, p = 0.031), absence of lymphatic invasion (56.0% vs. 40.8%, p = 0.003), low CEA level (57.1% vs. 42.2%, p = 0.020), lower pathological stage (p = 0.022), no M stage (50.8% vs. 36.1%, p = 0.035), lower N stage (p = 0.002), microsatellite instability (MSI) status (p < 0.001), and anatomic tumor location (p = 0.030). Here, BRIP1 is linked to malignant colon neoplasm.