Maternal IL-6 concentrations were significantly elevated in PPROM compared with controls in both maternal serum (pooled SMD = 1.72; 95% CI: 1.15-2.29; <i>p</i> < 0.001) and amniotic fluid (SMD = 2.84; 95% CI: 2.01-3.67; <i>p</i> < 0.001). The gene discussed is IL6; the disease is preterm premature rupture of the membranes.