These studies suggest that activation of the Nrf2 pathway can provide both neuroprotective effects and slow down seizure progression by suppressing processes such as glial activation, inflammation, and mitochondrial dysfunction; in this context, the antioxidant and anti-inflammatory effects of CORMs via the Nrf2/HO-1 pathway support their potential as treatment candidates in epilepsy. This evidence concerns the gene HMOX1 and epilepsy.