While global methylation changes alone do not reliably predict gene expression, specific loci such as DSCAML1, BAIAP2L1, and SHANK1 display context-dependent regulatory patterns that may modulate tumor biology in a locus- and cohort-specific manner, reflecting a complex interplay between epigenetic modification, chromatin structure, and transcription factor occupancy [13]. The gene discussed is BAIAP2L1; the disease is neoplasm.