The decreasing percentage of TIGIT+ Tconvs upon hyperglycemia was associated with lower expression of GLUT1 and GLUT3, decreasing activity of G6PDH (pentose phosphate pathway producing glycolysis substrates), and lactate dehydrogenase (metabolizes pyruvate to lactic acid instead of incorporating it into the Krebs cycle). This evidence concerns the gene SLC2A1 and Hyperglycemia.