Low levels of YTHDF2 significantly increase the expression of LHPP (phospholysine phosphohistidine inorganic pyrophosphate phosphatase) and growth inhibitor NKX3-1 (NK3 homeobox 1), inhibit AKT phosphorylation, and significantly suppress the proliferation and migration of PCa cells. The gene discussed is NKX3-1; the disease is posterior cortical atrophy.