METTL14 affects the expression of transcription factor SOX4 (sex-determining region Y-box transcription factor 4), and the degradation of SOX4 mRNA depends on YTHDF2. Low levels of SOX4 increase the expression levels of PI3K and AKT proteins, activate glycolysis in stem cells, and have a certain inhibitory effect on the malignant process of CRC [108]. The gene discussed is YTHDF2; the disease is colorectal carcinoma.