EGFR and neoplasm: Although they lack the complexity of present-day organoids grown from tumor biopsies, they have provided invaluable insights into cancer biology, such as the discovery of the bidirectional cross-modulation of β1-integrin and epidermal growth factor receptor (EGFR) signaling, which enabled the restoration of the normal breast cell phenotype by down-modulating EGFR in certain tumor cells [104].