MAPT and Alzheimer disease: Consistently, an increase in tau hyperphosphorylation at several AD-relevant epitopes with mislocalization into the somatic compartment and high propensity to form insoluble aggregates are observed following the exposure to SARS-CoV-2 in human SH-SY5Y neuron-like cell line and transgenic mouse expressing human ACE2 (K18-hACE2), an animal model that does not completely reflect the human pathophysiology [173].