In a D-galactose-induced mouse model of premature ovarian insufficiency, Shang et al. [61] found that GPS specifically increased estradiol (E2) levels, decreased follicle-stimulating hormone (FSH) levels, and ameliorated pathological damage associated with ovarian insufficiency by inhibiting oxidative stress and granulosa cell apoptosis. The gene discussed is BRD2; the disease is premature menopause.