ERBB2 and cancer: Given that Src kinases have been implicated in the metastatic process, WISP1 (CCN4) has been increasingly recognized for its oncogenic role across various cancers [19,39], while higher WISP1 expression correlates with advanced disease characteristics, such as larger tumors, lymph node metastasis, and HER-2/neu overexpression [19,40,41,42].