One important observation from our study was that, contrary to previous findings [14,15,16,17] where it has been demonstrated that the activators stimulate ROS generation in numerous cell types, including VSMSCs and ECs, these activators (IL-6, PDGF, Ang II, and thrombin) did not increase mROS production in HSVSMCs from both non-diabetic and T2DM patients, even though we have previously established that these concentrations significantly increased JAK1/2-mediated phosphorylation of STAT3 or ERK1,2 phosphorylation [21]. This evidence concerns the gene MAPK3 and type 2 diabetes mellitus.