CXCL12 and neoplasm: Therefore, despite the fact that MCF7 cells do not acquire aggressive invasive potential when co-cultured with microenvironment cells, the interaction of CAFs and endothelial cells mediated by paracrine signals (LIF, SDF-1, HGF, SCGF-β) can be considered a potential therapeutic target for indirectly affecting the tumor epithelial compartment (Figure 5).