SCGF-β, in its capacity as a regulator of the maintenance of hematopoietic and cancer stem cells, exerts a synergistic effect with SDF-1α and bFGF by establishing niches that promote the maintenance of cancer cell populations and the differentiation of myeloid cells into suppressor populations, thereby facilitating the development of myeloid-derived immunosuppression [118]. Here, CXCL12 is linked to cancer.