Just as SCMCs (Krt5+/Sox9+/Myc+/YAP+) outcompete alveolar cells to drive bronchiolization in fibrosis, SCLC-Y cells utilize this high-fitness, high-metabolism state to remodel the tumor microenvironment, resist chemotherapy, and drive metastasis. This evidence concerns the gene YAP1 and small cell lung carcinoma.