Two of them had secondary infection, grade D aminotransferase levels according to the de Souza classification [29], severe thrombocytopenia, pleural effusion confirmed by chest X-rays, and required intravenous albumin administration, while the third had grade C aminotransferase levels according to the de Souza classification [29] and mild thrombocytopenia (Table 5). Here, ALB is linked to Pleural effusion.