In this proof-of-concept study using a near-term ovine model of prolonged asphyxial cardiac arrest, co-administration of dextrose and insulin with epinephrine was associated with a higher incidence of ROSC (5/5 vs. 3/6) Although the difference in ROSC incidence did not reach statistical significance due to the small sample size, the experimental group demonstrated improved early post-ROSC hemodynamics, including higher carotid blood flow at 5 min post-ROSC and better gas exchange, with lower PaCO2 and higher PaO2. This evidence concerns the gene INS and cardiac arrest.