In a near-term ovine model of prolonged asphyxial cardiac arrest, dextrose–insulin co-administration with epinephrine was associated with improved ROSC rates (5/5% vs. 3/6%, p = 0.18), with similar time to ROSC, enhanced early post-resuscitation hemodynamics (higher carotid blood flow at 5 min), and better gas exchange compared to epinephrine alone. The gene discussed is INS; the disease is cardiac arrest.