Biomarker-based predictive models incorporating platelet-to-lymphocyte ratio (PLR), white blood cell count (WBC), absolute neutrophil count (ANC), absolute lymphocyte count (ALC), neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP), and procalcitonin (PCT) have shown utility in distinguishing surgical from medical NEC cases [22]. This evidence concerns the gene CRP and necrotizing enterocolitis.