RNASE3 and asthma: Validated questionnaires (e.g., Childhood Asthma Control Test) [22], spirometry-based calculations (e.g., Global Lung Initiative equations) [23,24,25], or surrogate biomarkers (e.g., Exhaled breath condensate, urinary cysteinyl leukotriene E4, eosinophilic cationic protein) [26], were developed as means of assessing asthma control to facilitate timely intervention.