Zha et al. revealed that lysophosphatidylcholine (LPC), a metabolite derived from Bacteroides ovatus, alleviated cognitive impairment by suppressing ACSL4 expression via GPR119, thereby inhibiting ferroptosis, improving cognitive function, reducing neuroinflammation, and mitigating myelin degeneration [10]. The gene discussed is GPR119; the disease is Cognitive impairment.