Improved understanding of the genetic risk architecture may support earlier risk stratification and enable the future development of personalized strategies for GDM prevention and management, with particular emphasis on genetic polymorphisms in <i>SLC30A8</i>, <i>CDKAL1</i>, and <i>HHEX</i> genes consistently implicated in glucose homeostasis and β-cell integrity. The gene discussed is CDKAL1; the disease is gestational diabetes.