The siRNA silencing of TMEM98 curbed proliferation, invasion, and migration of A549 and H460 cells and downregulated MMP-2, MMP-9, RhoC (Ras homolog family member C), and MTA1 (metastasis associated 1) [122], indicating that TMEM98 fuels NSCLC aggressiveness. The gene discussed is TMEM98; the disease is non-small cell lung carcinoma.