Nuclear division cycle 1 homolog (NDC1 or TMEM48), a transmembrane nucleoporin that resides at the nuclear pore complex (NPC) and the inner nuclear envelope [46,47,48], is markedly upregulated in hepatocellular carcinoma [48,49], NSCLC [46,50], cervical cancer [51], and pancreatic cancers [52]. This evidence concerns the gene NDC1 and familial pancreatic carcinoma.