CD274 and non-small cell lung carcinoma: In non-small cell lung cancer (NSCLC), ORAI1 is markedly overexpressed, accelerating tumor progression by amplifying PI3K–AKT–ERK (phosphoinositide 3-kinase, protein kinase B, and extracellular signal-regulated kinase) signaling [40], increasing PD-L1 (programmed death-ligand 1) -bearing exosome release, and blunting antitumor T-cell response [39].