TMEM176A and non-small cell lung carcinoma: Although an earlier study reported elevated TMEM176A protein levels in lung tumors versus normal tissue [111], Li et al. [99] later showed that promoter hypermethylation downregulates TMEM176A in NSCLC, whereas its re-expression induces apoptosis and G2 and M arrest and suppresses migration, invasion, proliferation, colony formation, and H1299 xenograft growth [99].