In A549 cells, TMEM116 knockdown downregulates PDPK1 (3-phosphoinositide-dependent protein kinase 1; historically referred to as PDK1) and suppresses proliferation, clonogenicity, invasion, and migration in vitro, as well as metastatic burden and subcutaneous tumor growth in vivo [124]. The gene discussed is TMEM116; the disease is neoplasm.