High-grade tumors show even greater ORAI3 abundance, which intensifies SOCE, accelerates G1–S transition through cyclin D1/CDK4 and Akt phosphorylation [42,43,44], and correlates with metastasis and shortened overall and metastasis-free survival in NSCLC tumors [42,43]. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.