Integrated analyses of The Cancer Genome Atlas-Colon Adenocarcinoma (TCGA-COAD) and Gene Expression Omnibus (GEO, GSE17538) datasets revealed significant upregulation of <i>SIAH2</i> and <i>WNK1</i> in CRC tissues, with strong positive correlations to glycolysis- and hypoxia-associated genes, including <i>PFKP</i>, <i>LDHA</i>, <i>BPGM</i>, <i>ADH1A, ADH1B,</i> and <i>HIF-1α</i>. Here, SIAH2 is linked to colon adenocarcinoma.