MRAP2 and type 2 diabetes mellitus: Utilizing exome sequencing data from large database (the Accelerating Medicine Partnership Type 2 Diabetes Knowledge Portal), it was shown that missense or protein-truncating MRAP2 mutations (with MAF < 1%) are significantly associated with higher BMI (p = 3.49 × 10−4 with b = 0.0364 kg m−2, 95% CI: 0.0165–0.0564 kg m−2) and have a stronger association (p = 2.36 × 10−5 with b = 0.154 kg m−2, 95% CI: 0.0828–0.226 kg m−2) in deleterious missense or protein-truncating MRAP2 mutations [23].