Our results also indicated a positive association between the MRAP2 R125C and obesity, with an OR of 2.45 and a non-significant p-value of 0.12 and a wide 95% CI (0.80–7.45) (Table 3), suggesting that this estimate is compatible with both a moderate effect and no effect. Here, MRAP2 is linked to obesity due to melanocortin 4 receptor deficiency.