CERs include over 200 distinct molecules generated Via de novo synthesis or cleavage of membrane precursors [205].The presence of low ceramide synthase 6 (CerS6) expression in melanoma cells has been correlated with malignant behavior, as evidenced in human melanoma cell lines WM35, WM451, and SKMEL28 [206]. The gene discussed is CERS6; the disease is melanoma.