In mouse melanoma cells, DHC treatment significantly downregulated the melanogenesis-related genes: Microphthalmia-associated Transcription Factor (MITF), tyrosinase (TYR), and Tyrosinase-related protein 1 (TRP1) compared with the α-MSH control (p < 0.05; Figure 3B). The gene discussed is STAMBP; the disease is melanoma.