By multivariable logistic regression, after applying frequency and functional impact filters, five coding variants meeting these criteria were retained for further analysis and as a result nominally associated with severe COVID-19 (AGXT2 rs37369, PLA2G7 rs1805018, RSPH4A rs140079844, LAMA5 rs111653839, IFNAR2 rs2229207; Table S1). This evidence concerns the gene IFNAR2 and COVID-19.