It was reported that expression levels of serine/arginine repetitive matrix 2 (SRRM2) and polyglutamine binding protein 1 (PQBP1, the splicing regulatory protein relating to an intellectual disability) were slightly lower in the postmortem cerebral cortex in AD patients, and that ERK1/2 had a role in phosphorylation of SRRM2 at Ser1068 [40]. The gene discussed is MAPK3; the disease is Alzheimer disease.