PTPRC and neoplasm: Mechanistically, PTPRC enhances Wnt/β-catenin signaling by reducing β-catenin tyrosine phosphorylation, preventing its degradation, and promoting nuclear accumulation that, in turn, increases the transcription of Wnt target genes, thereby supporting CSC survival, self-renewal, and metastatic potential and highlighting a tumor-intrinsic role for PTPRC in promoting chemoresistance and progression.