LAMB2 and neoplasm: Evidence of ECM-driven proliferation of OC cells was initially shown in various in vitro cell culture experiments using Hey-A8, OVCAR-3 and Peo.36 cell lines, all of which laminin is overexpressed in OC compared to healthy tissues, particularly the variant laminin a5, which is associated with poor prognosis; genetic knockdown of LAMA5 was shown to inhibit tumor growth and metastasis in vivo by attenuating Notch signaling [44].