In OC, several important findings have emerged: first, there is an inverse correlation between tumor fibrosis levels and both recurrence-free and overall survival [23]; second, serum levels of angiotensin-converting enzyme (ACE), which is responsible for converting inactive angiotensin I (AT1) to the biologically active AngII, are increased [24]; and third, high AT1 expression levels are associated with adverse patient outcomes. Here, ACE is linked to neoplasm.