CXCL8 and Behcet disease: Furthermore, serum levels of cytokines, and chemokines such as IL-1, IL-2, IL-8, IL-12, IL-17, IL-22, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ) or their receptors have been reported in patients with active BD [12,13,14].