Importantly, elevated expression of LD associated proteins—such as perilipins (PLIN2/PLIN3), adipophilin, FASN, and stearoyl-CoA desaturase 1 (SCD1)—has been correlated with higher tumor grade, increased metastatic potential, and poorer patient survival, supporting their utility as biomarkers for disease progression and therapeutic response [50,51]. This evidence concerns the gene PLIN2 and neoplasm.