Kawabata et al. extended these findings by demonstrating that PAR-2, but not PAR-1, stimulation induces MEK1/2 and ERK1/2 phosphorylation in DLD-1 CRC cells, with the MEK inhibitor PD98059 completely abolishing PAR-2 mediated proliferation [39]. Here, MAPK3 is linked to colorectal carcinoma.