MAPK1 and cancer: Finally, the downstream biology measured here, including PAR 2 attenuation, ERK suppression, and apoptosis, is mechanistically compatible with the canonical mevalonate isoprenoid depletion model in which statin mediated restriction of farnesyl and geranylgeranyl intermediates suppresses prenylation dependent signalling nodes such as Ras and Rho family GTPases that converge on ERK-driven survival circuitry, with multiple cancer model studies supporting mevalonate pathway dependence through intermediate rescue logic [55,56].