HMOX1 and myocarditis: ICI-related myocarditis reduced the expressions of nuclear Nrf2 (0.47 ± 0.06), total Nrf2 (0.74 ± 0.30), and HO-1 (0.88 ± 0.12) compared with the control group (nuclear Nrf2, 1.06 ± 0.11; total Nrf2, 1.44 ± 0.26; HO-1, 1.69 ± 0.43; Figure 6A).